By utilizing the intrinsic characteristic of upstream swimming of sperm to against an appropriate fluid velocity, the present sperm sorting microfluidic chip could increase sperm motility of infertile males up to 80% in just 40 minutes.
The microchannel of our chips is specially designed to be divergent to ensure appropriate fluid velocity for the high motile sperm to swim upstream into the divergent channels, whereas the low motile and nonviable sperm would be just washed away into wasted chamber.
Because of our special design, the appropriate fluid velocity for separating high motile sperm could be sustained by just loading fluid to the inlet chamber without the necessity of additional powered device. Thus, it is more convenient to operate on.
The present sperm sorting microfluidic chip could yield high motile sperm for subsequent infertility treatments in IUI, IVF or ICSI.