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技術名稱:

監測及紀錄病毒感染歷程及篩選疫苗之方法及系統
Method and system for monitoring and recording a viral infection process and that for screening vaccines

單位名稱:

國立臺灣海洋大學
National Taiwan Ocean University

技術說明:

一種病毒致病歷程紀錄暨疫苗快速篩選系統,將細胞與水膠材料成形固化於微型懸臂樑感測器結構上,隨後通入含有病毒之溶液,隨著病毒接觸細胞、於細胞內複製、脫離細胞,微型懸臂樑感測器結構將有不同程度之變形量,即可藉由聲、光、電、磁等方法測得微型懸臂樑感測器結構變形量,進而紀錄病毒致病歷程。亦可通入含有疫苗之溶液,隨著有效之疫苗接觸細胞,微型懸臂樑感測器結構將變形,也可藉由聲、光、電、磁等方法測得微型懸臂樑感測器結構是否變形,達到疫苗快速篩選之目的。

The present invention relates to a detection technology, which can be used for monitoring and recording a viral infection process in host cells and that for screening effective vaccines, characterized by providing a microcantilever detection device, which comprises a microcantilever comprising a contact area having an macromolecular material attached thereon; allowing host cell to be fixed in the macromolecular material; allowing a sample containing a test virus or vaccine to be loaded into the contact area to make the test virus or vaccine to contact the host cells fixed in the macromolecular material so as to produce a deflection of the microcantilever; and recording the deflection in a time course manner so as to obtain a deflection profile that can used as a basis for determining the viral infection process or the potential efficacy of the vaccines.

發明人:

吳志偉

連絡資訊:

羅晏如 24622192